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CML also known as: Chronic myeloid leukemia, chronic myelogenous. A type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood. CML occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to an overproduction of immature granulocytes. (In many cases people don't have any symptoms for a few years). In time, the cells can also invade other parts of the body, including the spleen. CML can change into a fast-growing acute leukemia that invades almost any organ in the body.
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